Table 1. Tyrosine Kinase Inhibition Activity of Compounds 1–3 and Nintedanib against Human Recombinant VEGFR2^a.

compound	IC50 (nM)
nintedanib	7
1	18
2	10
3	35

^aReported IC₅₀ values were determined by enzymatic radiometric assay (using [γ-³³P]-ATP) and are the average of two independent experiments.