Table 1.
Characteristics of the study population across rs1801260 genotypes
| Variables | Overweight (n = 221) | Obese (n = 182) | Total (n = 403) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype | P-value | Genotype | P-value | Genotype | P-value | |||||||
| TT (n = 99) | CT (n = 101) | CC (n = 21) | TT (n = 59) | CT (n = 91) | CC (n = 32) | TT (n = 158) | CT (n = 192) | CC (n = 53) | ||||
| Demographic variables | ||||||||||||
| Age(year) | 36.4 ± 9 | 35.7 ± 9 | 34.2 ± 9 | 0.653 | 36.3 ± 8 | 37.1 ± 7 | 38.8 ± 6 | 0.477 | 36.5 ± 8 | 36.4 ± 8 | 37.1 ± 8 | 0.83 |
|
Physical activity (Met-minute/w) |
1804 ± 1049 | 1531 ± 1002 | 1272 ± 858 | 0.052 | 1770 ± 1277ab | 1129 ± 978a | 825 ± 555b | 0.001 | 1792 ± 1134ab | 1334 ± 1008a | 996.7 ± 713b | 0.001 |
| Anthropometric factors | ||||||||||||
| Weight(kg) | 79.5 ± 7 | 80.7 ± 7 | 81.1 ± 10 | 0.491 | 90.8 ± 10 | 92 ± 8 | 95.7 ± 10 | 0.072 | 83.7 ± 10a | 86.3 ± 9 | 90.1 ± 12a | 0.001 |
| Height (cm) | 164.7 ± 7 | 165 ± 7.5 | 164.1 ± 9 | 0.36 | 165.1 ± 8 | 164.1 ± 6 | 164.8 ± 7 | 0.69 | 165.1 ± 7 | 164.6 ± 7 | 164.2 ± 8 | 0.59 |
| BMI(kg/m2) | 27.9 ± 1.1 | 27.5 ± 1.4 | 28.2 ± 1 | 0.06 | 32.1 ± 3.1a | 32.6 ± 1.9 | 34.1 ± 3.2a | 0.01 | 29.6 ± 2a | 30.3 ± 2 | 31.6 ± 4a | 0.001 |
| WC (cm) | 94.6 ± 6.7 | 94.2 ± 7.5 | 96 ± 6.9 | 0.627 | 102.1 ± 8a | 104.6 ± 7 | 106.9 ± 7a | 0.017 | 97.3 ± 8a | 99.2 ± 9 | 102.7 ± 8a | 0.001 |
| Food intake | ||||||||||||
| Energy (kcal/day) | 1869 ± 259ab | 1946 ± 272a | 2012 ± 238b | 0.033 | 2486 ± 407ab | 2527 ± 285a | 2695 ± 486b | 0.048 | 2096 ± 437ab | 2232.4 ± 416a | 2434 ± 526b | ˂0.001 |
| Carbohydrate (kcal/day) | 322 ± 31a | 326 ± 36b | 304 ± 28ab | 0.037 | 330 ± 54a | 311 ± 38b | 333 ± 44ab | 0.006 | 310.1 ± 80a | 322.8 ± 66b | 355 ± 92ab | 0.001 |
| Protein (kcal/day) | 86 ± 12 | 83.2 ± 12 | 81.5 ± 10 | 0.201 | 87.3 ± 22 | 79.3 ± 19 | 79.1 ± 21 | 0.075 | 82.8 ± 25.2 | 82.2 ± 20.5 | 87.9 ± 25 | 0.18 |
| Fat (kcal/day) | 63.1 ± 12ab | 78.6 ± 18a | 72 ± 17b | ˂0.001 | 67.8 ± 12ab | 73.8 ± 15a | 84 ± 17b | ˂0.001 | 62.5 ± 18ab | 77 ± 24.2a | 84.4 ± 22b | ˂0.001 |
| Qualitative variables | ||||||||||||
| Males(%) | 58.2(53) | 54.5(60) | 66.7(12) | 0.602 | 47.2(25) | 49.5(50) | 44.8(13) | 0.895 | 54.2(78) | 51.9(110) | 53.2(25) | 0.899 |
| Married(%) | 78(71) | 72.7(80) | 66.7(12) | 0.056 | 88.7(47) | 77.2(78) | 96.6(28) | 0.063 | 81.9(118) | 75(159) | 85.1(40) | 0.080 |
| University graduate (%) | 61.5(56) | 73.6(81) | 72.2(13) | 0.173 | 45.3(24) | 63.4(64) | 62.1(18) | 0.086 | 55.6(80) | 68.4(145) | 66(31) | 0.064 |
|
Current smoker (%) Occupation (%) |
2.2(2) | 1.8(2) | 0 | 0.962 | 3.8(2) | 6.9(7) | 3.4(1) | 0.182 | 2.8(4) | 4.2(9) | 2.1(1) | 0.676 |
| Unemployed | 41.8(38) | 38.2(42) | 38.9(7) | 0.981 | 49.1(26) | 47.5(48) | 51.7(15) | 0.699 | 44.4(64) | 42.9(91) | 46.8(22) | 0.909 |
| Government employee | 33(30) | 31.8(35) | 27.8(5) | 22.6(12) | 24.8(25) | 24.1(7) | 29.2(11) | 28.3(11) | 25.5(12) | |||
| Worker | 6.6(6) | 7.3(8) | 11.1(2) | 9.4(5) | 3(3) | 3.4(1) | 7.6(11) | 5.2(11) | 6.4(3) | |||
| Self-employment | 18.7(17) | 22.7(25) | 22(4) | 18.9(10) | 24.8(25) | 20.7(6) | 18.8(27) | 23.6(50) | 23.1(10) | |||
Variables are presented as mean ± SD for continuous variables and percent (%) for categorical variables. P-value is found by ANCOVA and adjusted for age, sex, physical activity, and total energy intake (residual method), except for dietary energy intake, which was only adjusted for age, sex and physical activity and for PA, which was only adjusted for age, sex and total energy intake. a, b: Significant difference between genotype by ANCOVA with Tukey's post hoc tests. Significant items with a P value ˂ 0.05 are bolded