. 2022 Jun 2;22:147. doi: 10.1186/s12902-022-01063-x

Table 2.

Behavioral and biochemical parameters of the study population across rs1801260 genotypes

Variables		Overweight (n = 221)				Obese (n = 182)				Total (n = 403)
		Genotypes			P-value	Genotypes			P-value	Genotypes			P-value
		TT (n = 99)	CT (n = 101)	CC (n = 21)		TT (n = 59)	CT (n = 91)	CC (n = 32)		TT (n = 158)	CT (n = 192)	CC (n = 53)
Behavioral factors
VAS. score		46 ± 18^ab	38 ± 19^a	28 ± 11^b	0.009	39 ± 19^ab	25 ± 18^a	17 ± 11^b	0.007	43 ± 19^ab	32 ± 21^a	21 ± 18^b	˂0.001
ME. score		63 ± 7.6^ab	52 ± 6.9^a	47 ± 6.8^b	˂0.001	62 ± 8^ab	50 ± 6^a	47 ± 6^b	˂0.001	63 ± 7.7^ab	51 ± 7.7^a	47 ± 6.8^b	˂0.001
Sleep (h/day)		8.3 ± 1^a	8 ± 0.9	7.7 ± 1.4^a	0.01	8.5 ± 1^a	8.1 ± 0.7	8 ± 0.6^a	˂0.001	8.4 ± 1^ab	8.1 ± 0.8^a	7.6 ± 0.9^b	˂0.001
Food timing (h)	Breakfast	7.7 ± 0.9^ab	8.4 ± 0.9^a	9.4 ± 1.2^b	˂0.001	7.8 ± 0.8^ab	8.9 ± 1.1^a	9.2 ± 0.9^b	˂0.001	7.8 ± 0.9^ab	8.6 ± 1^a	9.3 ± 1^b	˂0.001
	Lunch	13.7 ± 0.7^ab	14.2 ± 0.8^a	14.9 ± 0.9^b	˂0.001	13.7 ± 0.8^ab	14.7 ± 0.9^a	15.1 ± 1^b	˂0.001	13.7 ± 0.7^ab	14.5 ± 0.9^a	15.1 ± 0.9^b	˂0.001
	Dinner	20.2 ± 0.8^a	20.8 ± 0.8	21.6 ± 0.6^a	˂0.001	20.2 ± 0.8^ab	21.2 ± 0.9^a	21.4 ± 0.9^b	˂0.001	20.2 ± 0.8^ab	21 ± 0.9^a	21.5 ± 0.8^b	˂0.001
Hormonal factors
GLP-1 (pg/ml)		47.3 ± 19	60 ± 16	42.1 ± 22	0.28	61.1 ± 16^ab	54.1 ± 16.3^b	38.8 ± 19^b	0.02	53.3 ± 19^a	56.4 ± 16	40.4 ± 20^a	0.02
Ghrelin (ng/ml)		0.84 ± 0.4	0.8 ± 0.1	0.78 ± 0.5	0.64	0.87 ± 0.2^a	0.92 ± 0.3	1.1 ± 0.9^ab	0.048	0.86 ± 0.3	0.87 ± 0.2	0.94 ± 0.7	0.98

VAS Visual analog scale, ME Morning-evening type, GLP-1 Glucagon-like peptide-1, S Short, M Medium, L Long; Variables are presented as mean ± SD for continuous variables and percent (%) for categorical variables. P-value is found by ANCOVA and adjusted for age, sex, physical activity, and total energy intake. ^{a, b} Significant difference between genotype by ANCOVA with Tukey's post hoc tests. Significant items with a P value ˂ 0.05 are bolded