TABLE 2.

Brain regions with significant differences in ReHo between the HC and SM groups.

ReHo	Brain areas	MNI coordinates
		X	Y	Z	BA	Peak voxels	t-Value
HC > SO
1	RMFG	54	0	51	6	85	7.28
HC < SO
2	LC	−27	−21	−45		256	−9.61
3	RFG	51	−18	−45	20	108	−7.78
4	LITG	−54	−18	−39	20	107	−8.74
5	LRG	−12	24	−30	25	266	−9.38
6	RT	6	3	18		109	−8.87
7	RC	24	−42	33		109	−6.72
8	LI	−36	−21	27	13	97	−5.91
9	LT	−12	−33	15		80	−8.25

For fMRI data, two-sample t-test was performed to examine the voxel-wise difference between the SM and HC groups using the REST toolbox. The statistical threshold was set at the voxel level with P < 0.05, FDR corrected, and cluster size >100 voxels for multiple comparison. These voxels were regarded as the regions of interest showing significant difference between the two groups. ReHo, regional homogeneity; HCs, healthy controls; SM, severe obesity and meibomian gland dysfunction; RMFG, right middle frontal gyrus; LC, left cerebellum; RFG, right fusiform gyrus; LITG, left inferior temporal gyrus; LRC, left rectus gyrus; RT, right thalamus; RC, right caudate; LI, left insula; LT, left thalamus.