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. Author manuscript; available in PMC: 2022 Jun 2.
Published in final edited form as: Clin Cancer Res. 2019 Mar 1;25(13):4168–4178. doi: 10.1158/1078-0432.CCR-18-2146

Figure 5: The association of miRNA-363 with CACNA1C expression and rituximab-induced apoptosis.

Figure 5:

(A) The miRNA-363 inhibited the luciferase activity in 293T cells with wild-type (WT) 3’UTR of CACNA1C gene, but did not affect it in cells with mutant 3’UTR of CACNA1C gene (p<0.01). (B) The ectopic expression of miRNA-363 reduced CACNA1C and CD20 protein expression in OCI-ly7 and OCI-ly8 cell lines. (C) The ectopic expression of miRNA-363 decreased rituximab-induced apoptosis in OCI-ly7 and OCI-ly8 cell lines (p<0.05). (D) The knockout of miRNA-363 led to the upregualtion of CACNA1C expression and (E) the increase of rituximab-induced apoptosis (p<0.05).