Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Two-step mechanism of NLRP3 activation. (A) TLR/IL1-R engagement leads to NF-κB activation driving transcriptional upregulation of inflammasome components (Signal 1). NLRP3 is then activated upon sensing unknown direct agonists (Signal 2), which can be (B) infectious, (C) sterile and can also be mediated through (D) exosomes.
