Table 1.

Response Profiles of Monotreme TAS2Rs, Eutherian TAS2R16, and Marsupial TAS2R705.

	Oan							Tac			Hsa	Bta	Laf	Mdo	Dvi	Sha	Meu	Pci
Compound/TAS2R	801	802	810	811	812	813A	813B	802	813	814	16	16	16C	705	705	705	705B	705C
Acesulfame K	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
Arbutin	—	—	—	●	—	—	—	—	—	—	●	●	●	—	●	—	●	●
Caffeine	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
Camphor	—	—	●	●	—	—	●	—	—	—	—	—	—	—	—	—	—	—
Chloramphenicol	—	—	—	●	—	●	—	—	—	—	—	—	●	—	—	—	—	—
Colchicine	—	—	—	—	●	●	●	—	●	—	—	—	—	—	—	—	—	—
Coumarin	—	—	—	—	—	—	—	—	—	—	—	●	—	—	—	—	—	—
Denatonium benzoate	—	—	●	●	●	●	—	—	●	—	—	●	—	—	—	—	—	—
Diphenidol	—	—	—	—	●	—	—	—	—	—	—	—	—	—	—	—	—	—
Flufenamic acid	—	—	—	—	—	—	—	—	—	●	—	—	—	—	—	—	—	—
Helicin	—	—	—	●	—	●	—	—	—	—	●	●	●	—	●	—	●	●
Linamarin	—	—	—	●	—	—	—	—	—	—	●	●	●	—	●	—	●	●
Noscapine	—	—	—	●	—	—	—	—	—	—	—	—	—	—	—	—	—	—
Phenylthiocarbamide	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
Picrotoxin	—	—	—	●	—	—	—	—	—	—	—	—	—	—	—	—	—	—
Quinine	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
Saccharin	—	—	—	—	—	—	●	—	—	—	—	—	—	—	—	—	—	—
Salicin	—	—	—	●	—	●	—	—	●	—	●	●	●	—	●	—	●	●
Sinigrin	—	—	—	●	—	●	—	—	—	—	—	—	●	—	—	—	—	—
Sodium benzoate	—	—	—	●	—	—	—	—	—	—	—	—	—	—	—	—	—	—
Sodium thiocyanate	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
Strychnine	—	—	—	●	●	—	—	—	—	—	—	—	—	—	—	—	—	—
Thiamine	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
Yohimbine	—	—	—	—	—	●	—	—	●	—	—	—	—	—	—	—	—	—
Total	0	0	2	12	4	7	3	0	4	1	4	6	6	0	4	0	4	4

Identified agonists are presented as dots in each TAS2R column. Agonists are detected by the statistical comparisons between fluorescence values (ΔF/F) of TAS2R-expressing and mock-transfected cells (n = 3–5) using Dunnett’s test (p < 0.01). β-glucoside analogs are presented in boldface. The number of compounds that activated each TAS2R is presented in the bottom row. Species abbreviations are as follows; Oan, platypus; Tac, echidna; Hsa, human; Bta, cattle; Laf, elephant; Mdo, opossum; Dvi, quoll; Sha, Tasmanian devil; Meu, wallaby; Pci, koala.