Figure 2.

Heterozygous kidney specific expression of a dominant negative RIαB allele partially inhibits PKA activity and ameliorates PKD in Pkd1^RC/RC mice. (A) Body weights, relative kidney weights, cyst indices, and urine outputs of RIαB-expressing mice and controls. (B) Cross-sections stained with hematoxylin and eosin of representative kidneys of RIαB-expressing (Pkd1^RC/RC;Pkhd1-cre;Pkrar1α^RIαB/WT mice and Pkd1^RC/RC;Pkrar1α^RIαB/WT controls; two RIαB expressing mice had unilateral hydronephrotic kidneys. (C) PKA activities and cAMP levels in kidney tissue lysates of RiαB-expressing mice and controls.