Figure 5.

Administration of BLU2864 by oral gavage ameliorates PKD in vivo in Pkd1^RC/RC mice. (A) Similar growth rates in BLU2864 treated and control mice. (B) Kidney volumes measured by magnetic resonance imaging in the treated and control group were similar at randomization, but significantly lower in the treated mice at the end of treatment at 16 weeks of age. (C) Representative coronal magnetic resonance images in BLU2864-treated and control mice at the end of treatment. (D) Cross-sections stained with hematoxylin and eosin of representative kidneys from BLU2864 treated and control mice at sacrifice. (E and F) Relative kidney weights and cyst indices in BLU2864-treated and control mice at sacrifice. (G and H) Kidney PKA activities and cAMP levels at sacrifice.