Table 2.
Genetic association of ΔCFHR3-CFHR1 with C3G in the Spanish population
| ΔCFHR3-CFHR1 status | Control (n=188) | C3G Cohort 1 (n=89) | C3G Cohort 2 (n=217) | ||||
|---|---|---|---|---|---|---|---|
| n (%) | n (%) | OR (95% CI) | P Value | n (%) | OR (95% CI) | P Value | |
| Genotype ΔCFHR3-CFHR1 | |||||||
| No deletion (%) | 113 (60) | 67 (75) | 2.02 (1.15 to 3.55) | 0.01 | 158 (73) | 1.78 (1.17 to 2.70) | 0.008 |
| Heterozygous (%) | 64 (34) | 18 (20) | 0.49 (0.27 to 0.89) | 0.02 | 52 (24) | 0.61 (0.40 to 0.94) | 0.03 |
| Homozygous (%) | 11 (6) | 4 (5) | 0.76 (0.23 to 2.45) | 0.64 | 7 (3) | 0.54 (0.20 to 1.41) | 0.23 |
| AF ΔCFHR3-CFHR1 | 0.229 | 0.146 | 0.58 (0.36 to 0.93) | 0.03 | 0.152 | 0.61 (0.42 to 0.86) | 0.007 |
AF, allele frequency; OR, odds ratio.