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. 2022 Apr 20;13(4):10362–10372. doi: 10.1080/21655979.2022.2044734

Figure 1.

Figure 1.

HG treatment inhibits cell proliferation and activates the pyroptosis of RPE cells. ARPE-19 cells were treated with 0, 10, 50, or 100 mM glucose for 48 h. (a) RPE cell viability was measured using an MTT assay. (b, c) PI staining was performed to determine cell death. (d) Western blot analysis of the expression levels of hallmark proteins (nucleotide-binding domain leucine-rich repeats family protein 3, caspase-1, N-terminal of gasdermin, IL-1β, and IL-18) in cell pyroptosis. (e) The release of LDH. (f) The activity of caspase-1. (g) Reverse transcription-quantitative PCR detection of miR-192 expression in ARPE-19 cells following HG treatment. Experimental data are presented as the mean ± SD (n = 6). *P < 0.05, **P < 0.01. RPE cell, retinal pigment epithelial cell; HG, high glucose.