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. 2022 Apr 20;13(4):10362–10372. doi: 10.1080/21655979.2022.2044734

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Overexpression of FTO counteracts the regulatory role of miR-192 in retinal pigment epithelial cell pyroptosis. (a) Reverse transcription-quantitative PCR analysis of the transfection efficiency of FTO overexpression. (b) MTT detection of ARPE-19 cell viability under different treatment conditions. (c) Cell death detected by PI staining. (d) The release of LDH. (e) The activity of caspase-1. (f) The protein expression detected using Western blot. Experimental data are presented as the mean ± SD (n = 4). **P < 0.01, ***P < 0.001. FTO, FTO α-ketoglutarate dependent dioxygenase; miR-192, microRNA-192; HG, high glucose; NC, negative control.