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Fraxetin down-regulates the expression of PLK4 and phosphorylated PI3K/Akt in DU145 prostate cancer cells. DU145 cells were treated with 0, 10, 20 and 40 μM Fraxetin for 48 h, then (a-b) PLK expression was detected by RT-qPCR and western blot assays; (c) protein expression of phosphorylated PI3K and Akt was measured by western blotting. **P < 0.01 and ***P < 0.001 vs Control.
