Table 2.
HA production under different fermentation conditions by Streptococci sp
| Microorganism | Fermentation Mode (capacity) |
Culture medium nutrients | Fermentationparameters | Biomass/ HA yield/MW | References |
|---|---|---|---|---|---|
| S. equisubsp. zooepidemicus (ATCC 35246) | Batch 2 L | Marine by-products: Mussel processing wastewater (50 g L−1), tuna peptone (8 g L−1) | 500 rpm No aeration |
3.67 g L−1/ 2.46 g L−1/ 2.5MDa | [31] |
| S. zooepidemicus | Batch bioreactor | By-products: Sugarcane molasses and corn steep liquor | 500 rpm 1 vvm pH 6.7 |
3.48 g L−1/ 3.8MDa | (Amado et al., 2017) |
| S. equisubsp. zooepidemicus (ATCC 35246) | Batch 2.5 L | Maltose (g L−1) increasing Carbon source consumed in CDM | 600 rpm 1.3 vvm |
2 g L−1/ 2.14 g L−1/ 2.1 MDa |
(Chong andNelsen, 2003) |
| Streptococcussp. | Chemostatsbioreactor giving Continuousform | Chemically defined medium (CDM) | High dilution rate | HA production 25% higher than batch cultures | [32] |
| S. zooepidemicus G1 (mutant of ATCC 39920) | Batch5L with strategy plus pulsed carbohydrate added | Glucose (40 g L−1), polypeptone (20 g L−1), YE (10 g L−1) | 10–80% DO | 3.5 g L−1/ 2.19MDa | [33] |
| S. zooepidemicus WSH 24 | Fed-batch 7 L | Sucrose (70 g L−1), YE (25 g L−1) | 200 rpm 0.5 vvm |
16.3 g L−1/ 6.6 g L−1/ n.d. | (Liu et al., 2009) |
| S. equisubspzooepidemicus (ATCC 39920) | Batch 10 L | Sucrose (50 g L−1), casein hydrolysate (10 g L−1) | 400 rpm 2 vvm |
6.5 g L−1/ 5.1 g L−1/ 3.9 MDa | [34] |
| Streptococcus sp. ID9102 (KCTC 1139BP) | Batch 75 L | Glucose (4%), YE (0.75%), casein peptone (1%), Gln+Glu+ oxalic acid | 400rpm 0.5 vvm | 3 g L−1/ 6.94 g L−1/ 5.9 MDa | (Imet al., 2009) |
| S. zooepidemicus (ATCC 39920) | Batch 3 L | Glucose (20 g L−1), YE (10 g L−1 + acetoin and acetate | 300 rpm 1 vvm |
2.43 g L−1/ 2.15 g L−1/ n.d. | Wuet al., 2009 |
| S. equisubspzooepidemicus (ATCC 35246) | Batch 2 L | Glucose (60 g L−1), CDM | 600 rpm 1 vvm |
3.5 g L−1/ 4.2 g L−1/ 3.2MDa | [35] |
CDM: Chemically defined medium. NTG: N-methyl-N’-nitro-N-nitrosoguanidin. phbCAB genes: polyhydroxybutyratesynthesis genes. YE: yeast extract