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. 2022 Apr 12;13(4):9264–9273. doi: 10.1080/21655979.2022.2036904

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — OIP5-AS1 targets miR-34a and regulates PD-L1. Cell proliferation was analyzed by CCK-8 (a) and colony formation assay (b) in H23 and H22 cells. Both overexpression of OIP5-AS1 and PD-L1 significantly promoted cell proliferation, while silencing of OIP5-AS1 and overexpression of miR-34a had opposite effects. To further confirm the roles of above RNAs in cell proliferation, colony formation assay was conducted. Both OIP5-AS1 and PD-L1 overexpression significantly increased cell colony number. However, OIP5-AS1 silence and miR-34a overexpression had opposite effects. The proliferation (c) and colonies (d) was measured by Cell proliferation analysis in H23 and H22 cells transfected with siNC, siPD-L1, and siPD-L1+ miR-34a. *, p < 0.05.