Figure 1.

FABP4 inhibition attenuated retinal injury in a mouse model of DR.

A mouse model of DR was established by injection of 150 mg/kg STZ into C57BL/6 male mice. The diabetic mice were then treated with BMS309403, a selective small-molecular inhibitor of FABP4. The protein expression of FABP4 in retina tissue was detected by (A) immunohistochemical staining and (B) western blot. (C) The level of FABP4 in mice serum was measured using mouse FABP4 ELISA kit. (D) The blood glucose was monitored during the experiments. (E) The histological change of retina was assessed by H&E staining. (F) The vascular permeability was evaluated by Evans blue assay. ***p < 0.001 vs control; ##p < 0.01, ###p < 0.001 vs STZ.