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FABP4 inhibition promoted the activation of PPARγ signaling in DR model in vivo and in vitro.
(A) The protein expression of PPARγ in retinal tissues of diabetic mice was measured by western blot. ***p < 0.001 vs control; #p < 0.05 vs STZ. ARPE-19 cells were stimulated by HG to mimic DR in vitro. BMS3089403 was also used for treatment. The protein expression of (B) FABP4 and (C) PPARγ in cells of each group was measured by western blot. ***p < 0.001 vs MA; ###p < 0.001 vs HG.
