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. 2022 Mar 22;13(4):8000–8012. doi: 10.1080/21655979.2022.2048991

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — UBE2B and RAD18 expression are positively correlated with ZMYM2 protein levels in ovarian tumor tissues. (a) Proteins with potential interactions with UBE2B. The prediction was conducted using GeneMANIA. (b) The expression of RAD18 in the normal fallopian tube (GTEx-FT, n = 5) and ovary tissues (n = 88) (GTEx-OV) and ovarian cancer tissues in TCGA-OV (n = 418). (c) The expression of UBE2B, RAD18, and ZMYM2 in multiple ovarian cancer cell lines (OVTOKO, CAOV4, PEO1, A2780, and OVCAR3) and normal HOSE cells. (d-f) IHC staining images of UBE2B (d), RAD18 (e), and ZMYM2 (f) in 24 ovarian cancer tissues. Representative images of high (red frames) and low (blue frames) protein expression were provided in the right panels. **, p < 0.01.