FIGURE 1 |.

Mouse skeletal stem cell and downstream progenitors (13). Skeletal stem cells (SSCs) and their progenitors can be isolated from mice bones on the basis of distinctive immunophenotypes using flow cytometry. The mSSC is shown at the apex of the stem cell tree with differentiation into increasing fate restricted progenitors. The multipotent bone cartilage and stromal progenitor (BCSP) gives rise to mouse cartilage progenitors, mouse osteoprogenitors, mouse B lymphocyte stromal progenitors, mouse 6C3 stromal cells, and mouse hepatic leukemia factor expressing cells. The immunophenotype of the cell surface markers are shown for each cell (13, 34). This figure is adapted from Chan et al. (13).