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. 2022 Mar 18;13(4):8240–8254. doi: 10.1080/21655979.2022.2049471

Figure 5.

Figure 5.

High glucose inhibits the Sirt1/Nrf2 signaling cascade activity by increasing expression of miR-138-5p in retinal pigment endothelial (RPE) cells. (a) Expression of miRNAs by quantitative reverse-transcription PCR (qRT-PCR). (b, d) Expression levels of miR-138-5p in RPE cells determined by qRT-PCR. (c, e) Expression levels of miR-211-5p in RPE cells detected by qRT-PCR. (f) Protein levels of Sirt1 detected by Western blot analysis. (g) Protein levels of Nrf2 in RPE cells detected by Western blot analysis. * indicates p values < 0.05; ** indicates p values < 0.01.