Figure 2.

Overexpression of miR-30d-5p alleviates renal dysfunction in db/db mice.

(a) The relative expression of miR-30d-5p in renal tissues detected via Real-time PCR; (b) blood glucose test every 4 weeks; (c) weight check every 4 weeks; (d) creatinine measurement at 24 weeks of age; (e) urea nitrogen detected at 24 weeks of age; (f-h) inflammatory markers IL-6, IFN-γ and TNF-α contents in serum of db/db mice; (i) the pathological condition of renal tissues detected via HE staining; (j) the renal tissue apoptosis detected via TUNEL staining. The data were expressed as mean ± SEM, (b&c) n = 10; (a&d–j), n = 5; + P < 0.05, versus DHI + NC.