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. 2022 May 16;50(1):89. doi: 10.3892/ijmm.2022.5144

Figure 5.

Figure 5

Rg3 activates NRF2 signaling in pancreatic tissues from mice with AP. (A) Western blot analysis revealed that NRF2, HO-1, GPX4 and xCT expression was significantly reduced in pancreatic tissues from mice with AP. (B) Rg3 treatment significantly increased NRF2, HO-1, GPX4 and xCT expression. Each band represents tissue from each mouse in the specific group. *P<0.05, **P<0.01 and ***P<0.001 compared with the Con or AP group. NRF2, nuclear factor erythroid 2-related factor 2; HO-1, heme oxygenase 1; GPX4, glutathione peroxidase 4; xCT, cystine/glutamate transporter; AP, acute pancreatitis; Con, control; L-Rg3, low-dose Rg3 (20 mg/kg); H-Rg3, high-dose Rg3 (40 mg/kg).