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. 2022 May 12;61(1):81. doi: 10.3892/ijo.2022.5371

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Copyright: © Zhou et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Dynamic TLR7 expression in immune cells from LLC tumor-bearing mice. (A) TLR7 mRNA abundance in parental LLC, s.c. and metastatic tumors in C57BL/6 mice.^**P<0.01 compared with LLC. (B and C) Representative flow cytometry plots of TLR7 expression in (B) CD45⁻ and (C) CD45⁺ cells from LLC s.c. and metastatic tumors. (D) Histogram representing TLR7⁺CD45⁺ cells in bone marrow, SPL, LN and tumor samples at day 0, 8, 15, 22 and 30 in mice with LLC s.c. tumors (n=3). (E and F) TLR7 expression on (E) DCs, macrophages, MDSCs and (F) NK, CD4⁺ T and CD8⁺ T cells from LLC s.c. tumors at day 8, 15, 22 and 30 (n=3). (G-I) Dynamic changes in TLR7 expression on various immune cells from the SPL and LN of LLC tumor-bearing mice (n=3). The data are presented as the mean ± SEM. ^*P<0.05, ^**P<0.01, ^***P<0.001 and ^****P<0.0001 compared with day 0. TLR, Toll-like receptor; LLC, Lewis lung carcinoma; s.c., subcutaneous; SPL, spleen; LN, lymph nodes; DCs, dendritic cells; MDSCs, myeloid-derived suppressor cells; NK, natural killer; NS, not significant.