Table 4.

Multivariable Cox regression of variables influencing SCD events and HCM-related heart failure events.

	SCD events		HCM-related heart failure events
Variables	HR (95% CI)	P value	HR (95% CI)	P value
β-Blockers	0.82 (0.61–1.01)	0.05	0.82 (0.63–0.92)	0.01
RAAS inhibitors	NA	NA	0.92 (0.85–1.23)	0.13
NVT on ambulatory Holter	2.53 (1.91–3.25)	<0.001	1.37 (1.08–2.09)	0.02
Unexplained syncope	1.62(1.20–2.17)	0.04	1.22 (0.91–1.77)	0.35
Family history of SCD	1.82 (1.35–2.51)	<0.001	1.04 (0.91–1.27)	0.77
LVOTO	2.01(1.60–2.93)	<0.001	2.39 (1.90–3.02)	<0.001
MLVWT≥ 30 mm	1.52 (1.27–1.88)	0.02	1.53 (1.18–2.21)	0.03
Depression	2.33 (1.64–2.93)	<0.001	1.27 (1.14–1.94)	0.04
Anxiety	1.42 (1.12–2.04)	0.03	2.92 (1.73–4.03)	<0.001

SCD indicates sudden cardiac death; HCM, hypertrophic cardiomyopathy; HR, hazard ratio; CI, confidence interval; RAAS, rennin-angiotensin-aldosterone system; NA, not applicable; NVT, Non-sustained ventricular tachycardia; LVOTO, left ventricular outflow tract obstruction; MLVWT, maximum left ventricle wall thickness.