Table 5.

Multivariable analyses for the association between anxiety and depression and the risk of SCD events and HCM-related heart failure events.

Mental health condition, n	SCD events, n (%)	Adjusted HR (95% CI)	P value	Heart failure events, n (%)	Adjusted HR (95% CI)	P value
No anxiety, no depression (n = 479)	22 (4.6%)	Reference	NA	42 (8.8%)	Reference	NA
Anxiety only (n = 114)	14 (12.3%)	1.77 (1.33–2.83)	0.015	36 (31.6%)	2.89 (1.79–3.93)	<0.001
Depression only (n = 72)	13 (18.1%)	2.69 (1.56–3.67)	<0.001	21 (29.2%)	2.72 (1.57–3.78)	<0.001
Both anxiety and depression (n = 128)	27 (21.1%)	3.52 (2.24–4.67)	<0.001	50 (39.1%)	4.08 (2.76–5.91)	<0.001

SCD indicates sudden cardiac death; HCM, hypertrophic cardiomyopathy; HR, hazard ratio; CI, confidence interval; NA, not applicable.