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. 2022 Mar 31;79(6):904–913. doi: 10.1097/FJC.0000000000001268

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Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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FIGURE 8. — A, Immunohistochemical staining and semiquantitative analysis of HIF-1α, HE4, and NF-κBpP65 in the kidneys of different groups. B, Quantitative analysis of HIF-1α, HE4, and NF-κBpP65. SD rats were treated with or without dapagliflozin for 3 days. Immunohistochemical staining for these proteins (original magnification ×400. Compared with control, proteins significantly increased in the CIN but decreased in the dapagliflozin groups, *P < 0:05 vs. the DCM group; #P < 0:05 vs. the D group. n = 5 in each group). C, control group; D, diabetic rats.