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. 2021 May 26;12(12):2167–2181. doi: 10.1021/acschemneuro.1c00169

Figure 4.

Figure 4

Hoechst staining (blue) and Iba1 (red), showing coronal representative sections of rat brains in the proximity of the injection site: (A, B, C, D, E) aCSF; (A′, B′, C′, D′, E′) SAP-treated. The inset squares indicate the brain areas where the microglia density is shown: (B, B′) cortical area near the injection; (C, C′) correspondence to the injection site at the NBM nucleus; (D, D′) cingulate cortex; (E, E′) area of thalamic nuclei. Note the higher density of Iba-1 positive cells (microglia) in lesioned animal, which is more noticeable and extended at the lesion site in the NBM. Bar in (A) is 500 μm. Bar in (B) is 100 μm.