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. 2021 May 26;12(12):2167–2181. doi: 10.1021/acschemneuro.1c00169

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[³H]-Pirenzepine binding (A) and [³H]-oxotremorine binding (B) in rat brain coronal sections obtained from aCSF (n = 7) and SAP-treated rats (n = 9) that show the specific distribution of M₁ mAChR and M₂ mAChR, respectively. Note the increase of both the M₁ mAChR density in the hippocampus (A) and the M₂ mAChR density in the deepest layers of cortex (B) and in the anterior amygdala of SAP-treated rats. Note also the loss of both M₁ mAChR in the anterior amygdala (A) and M₂ mAChR in the NBM (B) following the lesion. The histograms show the mean ± SEM of each group in the different areas analyzed. Scale bar: 5 mm.