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. 2022 May 12;163(7):bqac064. doi: 10.1210/endocr/bqac064

Figure 1.

Figure 1.

Expression of retinoid-related genes in human and mouse enteroendocrine cells. (A) Schematic representation of retinoid metabolism. (B-D) Heat maps plotting expression of retinoic acid (RA) metabolism-related genes in published single cell and bulk RNA sequencing (RNAseq) datasets for (B) enteroendocrine cells (EECs), (C) K-cells, and (D) L-cells. Top 3 rows label region of the gut (darker blue labels more distal gut, white = whole small intestine (SI), * = combined colon and rectum); sample type (dark green = primary tissue, light green = organoids); and organism (pink = human, purple = mouse). Letters at the bottom label publication (a = Glass et al 2017, b = Roberts et al 2018, c = Larraufie et al 2019, d = Billing et al 2019, e = Goldspink et al 2020, f = Beumer et al 2018, g = Gehart et al 2019). Gene expression is plotted in log2 (counts per million). Expression for single cell RNAseq datasets (a, d, f, g) were calculated as the average across the cell type of interest.