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. Author manuscript; available in PMC: 2022 Jun 2.
Published in final edited form as: Psychoneuroendocrinology. 2016 Nov 30;77:203–210. doi: 10.1016/j.psyneuen.2016.11.028

Figure 3 : Insulin increased phospho-tau (pSer202/Thr205) in the cortex of APOE4 mice.

Figure 3 :

Western blots analysis of RAGE (A) and LRP1 (B) concentrations in brain capillaries 5 minutes after insulin or saline injection. Levels of soluble phosphorylated tau in response to insulin injection in cortex (C). Data for p-tau are presented compared to the average of saline-injected mice. Concentrations of phosphatases and cdk5 (D). Data are presented as mean ± SEM. Statistical analysis: Mann-Whitney test, &p<0.05 (A and B) or unpaired t-test, *p<0.05 (C and D). RAGE = receptor for advanced glycation end products. LRP1 = low density lipoprotein receptor-related protein 1. cdk5 = cyclin-dependent kinase 5. PP2AC = catalytic subunit of protein phosphatase 2A. PP2B = protein phosphatase 2B.