Table 3.
Genomic feature enrichment using two-sided Fisher's exact test.
| Genomic feature | Adult SES and BMI | Neighborhood socioeconomic disadvantage and HDL-C | ||
|---|---|---|---|---|
| Odds ratio | P-value | Odds ratio | P-value | |
| DHS | 0.95 | 0.768 | 4.91 | 2.03E-06 |
| Enhancer | 2.01 | 4.76E-11 | 4.79 | 4.84E-07 |
| Promoter | 0.52 | 5.55E-08 | 0.71 | 0.407 |
| Shore/shelf | 1.37 | 0.002 | 0.62 | 0.197 |
| CpG island | 0.11 | 1.77E-41 | 0.05* | 1.07E-06 |
| eQTM | 11.60 | 1.72E-59 | 11.89 | 8.17E-08 |
SES, socioeconomic status; BMI, body mass index; HDL-C, high-density lipoprotein cholesterol; DHS, DNase hypersensitive site; eQTM, expression quantitative trait methylation site.
An odds ratio smaller than 1 indicates depletion, and an odds ratio larger than 1 indicates enrichment.
Bold text indicates p < 0.05 after Bonferroni correction (p < 0.0083).
*No mediating CpGs for neighborhood socioeconomic disadvantage and HDL-C were present in CpG islands. In order to conduct the enrichment analysis, we added 1 to each cell of the contingency table to avoid having an odds ratio of zero.