Table 1.
Demographic and clinical features of the study cohort.
| Entire cohort (n = 49) | HC (n = 11) | AS (n = 5) | SM (n = 33) | P value | |
|---|---|---|---|---|---|
| Age, years (range 25 %–75 %) | 53.0 (45.0–66.0) | 40.0 (35.0–51.0) | 41.6 (23.5–61.0) | 59.9 (51.5–69.0) | <0.01 |
| Gender | 0.86 | ||||
| Female | 25 (51.0 %) | 6 (54.5 %) | 2 (40.0 %) | 17 (51.5 %) | / |
| Male | 24 (49.0 %) | 5 (45.5 %) | 3 (60.0 %) | 16 (48.5 %) | / |
| Mortality | 1 (2.0 %) | 0 | 0 | 1 (3.0 %) | 0.78 |
| Diagnostic tests | |||||
| Chest CT abnormal | 33 (67.3 %) | 0 | 0 | 33 (100 %) | <0.01 |
| Nucleic acid test (+) | 38 (77.6 %) | 0 | 5 (100 %) | 33 (100 %) | <0.01 |
| SARS-COV-2 IgM (+) | 22 (50 %) | 0 | 0 | 22 (66.7 %) | <0.01 |
| SARS-COV-2 IgG (+) | 36 (73.5 %) | 0 | 3 (60.0 %) | 33 (100 %) | <0.01 |
| Laboratory tests (SD) | |||||
| White blood cell count, ×109/L | 6.73 (2.84) | NA | 7.66 (2.93) | 6.58 (2.85) | 0.23 |
| Neutrophil count, ×109/L | 4.70 (2.72) | NA | 4.90 (2.19) | 4.67 (2.82) | 0.65 |
| Lymphocyte count, ×109/L | 1.30 (0.69) | NA | 1.79 (0.81) | 1.22 (0.66) | 0.12 |
| CRP, mg/L | 53.13 (36.10) | NA | 26.3 (n = 1) | 54.4 (36.48) | 0.58 |
| IL-2, pg/mL | 4.25 (1.90) | NA | 3.80 (0.46) | 4.33 (2.07) | 0.65 |
| IL-4, pg/mL | 3.07 (0.51) | NA | 2.99 (0.14) | 3.09 (0.56) | 0.77 |
| IL-6, pg/mL | 22.74 (52.43) | NA | 14.05 (16.69) | 24.12 (56.23) | 0.57 |
| IL-10, pg/mL | 8.02 (6.17) | NA | 10.26 (9.43) | 7.60 (5.72) | 0.82 |
| CD3, /μL | 838.94 (542.34) | NA | 1529.25 (264.62) | 749.87 (504.59) | 0.01 |
| CD4, /μL | 513.54 (325.23) | NA | 887.00 (225.54) | 465.35 (306.26) | 0.03 |
| CD8, /μL | 291.03 (222.41) | NA | 541.00 (143.77) | 258.77 (211.16) | 0.02 |
| CD19, /μL | 220.18 (155.09) | NA | 383.75 (116.52) | 199.07 (147.90) | 0.04 |
| IgM, g/L | 0.95 (0.35) | NA | 0.93 (0.54) | 0.95 (0.34) | 0.92 |
| IgG, g/L | 12.95 (4.86) | NA | 11.68 (2.43) | 13.04 (4.99) | 0.70 |
Notes: Data are n (%), age: median (ranging 25 %–75 %) or laboratory tests: mean with standard deviation (SD), unless otherwise stated. For statistical analyses, the Mann-Whitney U test was done for continuous variables which didn't conform to normal distribution and test for homogeneity of variance, and Pearson's χ2 test was done for categorical variables. Laboratory tests statistical analysis were conducted between with AS and SM group. P value <0.05 was considered as statistically significant. HC=healthy controls, AS = asymptomatic subjects, SM = symptomatic patients, NA = not available.