Figure 5.

Early detection of N mutations

Analysis of NMoI N:D377Y and of the three highly diffused N mutations originally detected as minor (in at least 5 samples) and only successively as fixed at the global scale, namely, N:L219F, N:A254S, and N:A254V. For further details please refer to the caption of Figure 2. N mutations first detected as minor at the local scale are shown in Figure S2 in the supplementary information.