Table 2.

Associations between HLA and tuberculosis.

Population	Study design	Sample size	Serotype, allele, SNP, or haplotype	Type of association	Ref.
Polish	Case-control	31 pulmonary TB patients and 58 healthy controls	HLA-DRB1∗16	Susceptibility	[29]
			HLA-DRB1∗13	Protection
Iranian	Case-control	40 pulmonary TB patients and 100 healthy controls	HLA-DRB1∗07 and HLA-DQA1∗01:01	Susceptibility	[30]
			HLA-DQA1∗03:01 and HLA-DQA1∗05:01	Protection
Uganda	Case-control	43 pulmonary TB patients and 42 healthy controls	HLA-DQB1∗03:03	Protection	[31]
Indian	Case-control	126 pulmonary TB patients and 87 healthy controls	HLA-DRB1∗15:01 and HLA-DQB1∗06:01	Susceptibility	[32]
			HLA-DPB1∗04	Protection
Icelander	Case-control	3,686 pulmonary TB patients, 14,723 patients with M. tuberculosis infection, 8,162 patients with any other forms of TB, and 277,643 healthy controls	rs557011[T] located between HLA-DQA1 and HLA-DRB1	Susceptibility to pulmonary TB and M. tuberculosis infection	[33]
			HLA-DQA1∗03	Susceptibility to M. tuberculosis infection
			rs9271378[G] located between HLA-DQA1 and HLA-DRB1	Reduced risk of pulmonary TB
Han Chinese	Case-control	4,310 TB patients and 6,386 healthy controls	HLA-DRB5 rs41553512	Susceptibility	[34]
Thai	Case-control	682 TB patients and 836 healthy controls	HLA-DRB1∗09:01 and HLA-DQB1∗03:03	Susceptibility to TB caused by modern M. tuberculosis strains	[35]