Table 3.

Associations between HLA and leprosy.

Population	Study design	Sample size	Serotype, allele, SNP, or haplotype	Type of association	Ref.
Indian	Case-control	32 leprosy patients and 67 healthy controls	HLA-A∗02:06, HLA-A∗11:02, HLA-B∗40:16, HLA-B∗51:10, and HLA-Cw∗04:07	Susceptibility	[37]
			HLA-A∗0101, HLA-Cw∗04011, and HLA-Cw∗06:02	Protection
			HLA-A∗11-B∗40, HLA-A∗11:02-B∗40:06-Cw∗04:07, and HLA-A∗11:02-B∗40:06-Cw∗15:02	Susceptibility to lepromatous leprosy
Indian	Case-control and family-based	258 leprosy patients, 161 families, and 300 healthy controls	HLA-DQA1 rs1071630 and HLA-DRB1 rs9270650	Susceptibility	[38]
Han Chinese	Case-control	3,254 leprosy patients and 5,955 healthy controls	HLA-DR-DQ rs602875	Susceptibility	[39]
Han Chinese	Case-control	305 leprosy patients and 527 healthy controls	HLA-DRB1∗15	Susceptibility	[40]
			HLA-DRB1∗09	Protection
Han Chinese	Meta-analysis	Four imputed data sets	HLA-DQA1∗03:03 and HLA-C∗08:01	Susceptibility	[41]
Brazilian	Case-control	578 leprosy patients and 691 healthy controls	HLA-DRB1∗10	Susceptibility	[42]
			HLA-DRB1∗04	Protection
Brazilian	Case-control	411 leprosy patients and 415 healthy controls	HLA-C∗12 and HLA-DPB1∗105	Susceptibility	[43]
			HLA-C∗08, HLA-DPB1∗04 and HLA-DPB1∗18	Protection
Vietnamese	Family-based	194 families	HLA-DRB1∗10	Susceptibility	[42]
			HLA-DRB1∗04	Protection
Vietnamese	Case-control	687 leprosy patients and 468 healthy controls	HLA-DQA1∗01:05 and HLA-DRB1∗10:01	Susceptibility	[44]
			HLA-C∗07:06	Protection
Argentinean	Case-control	142 leprosy patients and 162 healthy controls	HLA-DRB1∗14 :01 and HLA-DRB1∗14:06	Susceptibility	[45]
			HLA-DRB1∗08:08 and HLA-DRB1∗11:03	Protection
Taiwanese	Case-control	65 multibacillary leprosy patients and 190 healthy controls	HLA-DRB1∗04:05	Protection against multibacillary leprosy	[46]