Table 9.
Associations between HLA and hepatitis C.
| Population | Study design | Sample size | Serotype, allele, SNP, or haplotype | Type of association | Ref. |
|---|---|---|---|---|---|
| Thai | Case-control | 57 subjects with persistent HCV infection and 43 subjects with transient HCV infection | HLA- DRB1∗03:01 and HLA-DQB1∗02:01 | Persistent HCV infection | [97] |
| HLA-DRB1∗03:01-HLA-DQA1∗05:01-HLA-DQB1∗02:01 | Persistent HCV infection | ||||
| Multiracial US women | Case-control | 622 HCV RNA positive women and 136 HCV RNA negative women | HLA-B∗57:01, B∗57:03, HLA-Cw∗01:02, and HLA-DRB1∗01:01 | HCV clearance | [98] |
| HLA-DRB1∗03:01 | Persistent HCV infection | ||||
| Chinese | Case-control | 429 subjects with persistent HCV infection and 231 subjects with HCV clearance | HLA-A∗02:01 and HLA-DRB1∗11:01 | HCV clearance | [99] |
| Egyptian | Family-based and case-control | 162 Egyptian families (255 subjects with chronic hepatitis C, 108 persons who spontaneously cleared the virus, and 588 persons in the control group) | HLA-DRB1∗03:01:01 and HLA-DRB1∗13:01:01 | Persistent HCV infection | [100] |
| HLA-DRB1∗04:01:01, DRB1∗04:05:01, DRB1∗07:01:01, and DRB1∗11:01:01 | HCV clearance |