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. 2022 Jun 2;13(6):521. doi: 10.1038/s41419-022-04974-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Athymic nude mice were injected subcutaneously with Y79 and Y79-CR cells for 7 days and then given intraperitoneal treatment with 4OI (50 mg/kg, once every other day) at day 7 for 2 weeks. Tumor volumes were calculated weekly (two-way ANOVA with Tukey’s multiple comparisons test; data are presented as mean ± SD; n = 6 mice/group). B–I The indicated markers in serum or tumors as well as body weight at day 21 were assayed (one-way ANOVA with Tukey’s multiple comparisons test; data are presented as mean ± SD; n = 6 mice/group).