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. 2022 Jun 2;13(6):518. doi: 10.1038/s41419-022-04969-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a X-linked dominant hypophosphatemic rickets (XLH) pedigree diagram. b pBOBI-cs2-c-3HA-FGF23 plasmid vector schematic diagram (version of SnapGene 5.2; URL: https://www.snapgene.com/). c FGF23 cloned plasmid identified by double enzyme digestion. Lane 1 is plasmid digested with BamHI/XhoI; Lane 2 is DNA marker. d pBoBi-N-3*Flag-PHEX plasmid vector schematic diagram (version of SnapGene 5.2; URL: https://www.snapgene.com/). e PHEX cloned plasmid identified by double enzyme digestion. Lane 1 is plasmid; Lane 2 is plasmid digested with XbaI-BsrGI; and Lane M is DNA marker. f secPHEX cloned plasmid identified by double enzyme digestion. Lane 1 is plasmid, Lane 2 is plasmid digested with XbaI-AgeI, Lane M is DNA marker. g–j PHEX cloned gene sequencing map; g c.433 T (p.145*), 145 mut type; h c.433 G (p.145Glu*), 145 WT type; i c.2245 C(p.Trp749Arg), 749 mut type; and j c.2245 T (p.Trp749Arg), 749WT type.