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. 2022 Jun 2;13(6):518. doi: 10.1038/s41419-022-04969-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Wild-type PHEX and secPHEX proteins are mainly located in the cell membrane and cytoplasm, while the localization of p.Glu145* and p.Trp749Arg mutated PHEX and secPHEX proteins in the cells changes such that they are widely distributed. At the same time, the expression of mutant PHEX and secPHEX proteins decreases significantly, especially the p.Glu145* mutants. Scale bar, 8 μm.