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. 2022 Jun 2;12:9198. doi: 10.1038/s41598-022-12727-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cross-clade homosubtypic cross-reactivity measured by protein microarray. IgG profiles in response to trimerized influenza virus VN04 (A/VN/1203/2004) H5 vaccine formulated with different TLR agonists, with or without squalene oil-in-water emulsion (AddaVax). H5 antigens (horizontal axis) are full-length (HA0) HA variants that have been organized by clade (classifications from www.fludb.org). Signal intensities (vertical axis) are geometric means of each vaccine group (N = 4 mice). (A) minus AddaVax; (B) with AddaVax. Boxed, two VN04 H5 proteins on the array (expressed in human or insect cells) that correspond with immunizing H5 variant. Abbreviations, as Fig. 1.