Fig. 5. Spatial and topological determinants of structure-function coupling variability.

a Average connectivity distance calculated following⁵³, and correlated with the average coefficient of variation of the structure-function coupling from Fig. 3a. Scatter color and size represent the standard deviation. b Coefficient of variation of structure-function coupling compared to network embedding metrics derived from structural and functional networks. To account for the possible effects of outliers, we also estimated these relationships using the biweight midcorrelation (r = 0.0031; −0.0349; −0.1722; −0.1987; 0.1956; 0.1647) and percentage bend correlation (r = − 0.0152; − 0.0359; − 0.1605; − 0.1936; 0.1803; 0.2980)⁵⁵. c R² similarity between pairs of nodes calculated as the Pearson correlation between pairs of regional structure-function coupling averaged across subjects (d) R² similarity correlated with Euclidean distance. Colormap shows the density of the scatter plot. e R² similarity values grouped by structural connectedness and functional intrinsic networks.