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. 2022 Jun 2;13:2858. doi: 10.1038/s41467-022-30487-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — One YscV_C protomer is highlighted (orange surface) within the nonameric ring (gray surface). The cartoon representation of YscV_C is divided into the four subdomains: SD1 (red, residues 372–438 and 493–513), SD2 (yellow, residues 439–492), SD3 (green, residues 514–600), and SD4 (blue, residues 601–704). For clarity, YscX (cyan) and YscY (dark red) are shown only for this heterotrimer and are depicted as ribbon in (b–d). a The overall structure of the heterotrimer within the assembly shows that all interactions, except for the insertion of YscX’s C-terminus, are confined within one heterotrimer, i.e., YscY does not interact with a neighboring YscV subunit. b YscY interacts with SD4 via the loop of its first TPR (site A) and c with SD2 via the face of its C-terminal TPR (site B). d In chains FB, GB, KB, and LB, YscX exhibits density for an extended N-terminus which binds to SD1 and SD2 via a conserved ⁴⁶RLYP⁴⁹ motif (site C). Note that the exact positions of the side chains could not be determined at this resolution and are only included for completeness. e The C-terminus of YscX is inserted into the SD4–SD4 cleft. Both involved YscV_C subunits are shown as cartoon colored by subdomain. YscX is shown as ribbon with sidechains starting from L118.