Table 1.
Baseline characteristics, risk factors, medication, medical history and PET MPI results in patients with positive and negative SSO
| All patients (50) | Positive SSO (37) | Negative SSO (13) | P | |
|---|---|---|---|---|
| Baseline characteristics | ||||
| Median age (years), n (IQR) | 47 (25-62) | 47 (28–58) | 34 (21–69) | 0.851 |
| Male gender n (%) | 39 (78) | 28 (75.7) | 11 (84.6) | 0.503 |
| Weight (kg), n (± SD) | 79.6 (10.9) | 80.4 (10.8) | 77.3 (11.3) | 0.379 |
| Height (cm), n (± SD) | 175 (9) | 175 (9) | 178 (8) | 0.247 |
| BMI (kg/m2), n (± SD) | 25.9 (3.2) | 26.4 (3.0) | 24.4 (3.2) | 0.53 |
| Risk factors | ||||
| Diabetes mellitus, n (%) | 1 (2) | 1 (3) | 0 (0) | 0.549 |
| Dyslipidaemia, n (%) | 15 (30) | 12 (32) | 3 (23) | 0.527 |
| Hypertension, n (%) | 13 (26) | 11 (30) | 2 (15) | 0.31 |
| Family history, n (%) | 13 (26) | 10 (27) | 3 (23) | 0.78 |
| Smoking, n (%) | 19 (38) | 17 (46) | 2 (15) | 0.051 |
| Medication | ||||
| Aspirin, n (%) | 13 (26) | 9 (24) | 4 (31) | 0.649 |
| Beta blocker, n (%) | 10 (20) | 8 (22) | 2 (15) | 0.629 |
| ACE inhibitor, n (%) | 14 (28) | 10 (27) | 4 (31) | 0.796 |
| Statin, n (%) | 15 (30) | 10 (27) | 5 (39) | 0.439 |
| Patient history | ||||
| CAD, n (%) | 14 (28) | 10 (27) | 4 (31) | 0.796 |
| Myocardial infarction, n (%) | 7 (14) | 4 (11) | 3 (23) | 0.273 |
| Stenting, n (%) | 8 (16) | 5 (14) | 3 (23) | 0.418 |
| CABG, n (%) | 4 (8) | 1 (3) | 3 (23) | 0.02 |
| Nitrogen-13 ammonia PET | ||||
| Stress nitrogen-13 ammonia dose, MBq/mCi (IQR) | 264 (254–276)/7.14 (6.86–7.46) | 267 (254–274)/7.22 (6.86–7.41) | 258 (250–289)/6.97 (6.76–7.81) | 0.595 |
| Rest nitrogen-13 ammonia dose, MBq/mCi (IQR) | 513 (434–533)/13.86 (11.73–14.41) | 514 (453–537)/13.89 (12.24–14.51) | 509 (410–524)/13.76 (11.08–14.16) | 0.283 |
| Stress MBF (ml·min−1·g−1) (± SD) | 2.32 (0.72) | 2.37 (0.62) | 2.17 (0.95) | 0.373 |
| Rest MBF (ml·min−1·g−1) (IQR) | 0.73 (0.6–0.86) | 0.67 (0.58–0.83) | 0.77 (0.71–0.88) | 0.141 |
| MFR, (± SD) | 3.16 (0.93) | 3.38 (0.86) | 2.53 (0.84) | 0.003 |
Bold values indicate P < 0.05
SSO splenic switch-off, IQR interquartile range, SD standard deviation, BMI body mass index, ACE angiotensine converting enzyme, CAD coronary artery disease, CABG coronary artery bypass graft, MBF myocardial blood flow, MFR myocardial flow reserve