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. 2022 Jun 2;13:3079. doi: 10.1038/s41467-022-30741-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Evolutionary trees of QS synthases (a) and receptors (b). a The optimal tree with the sum of branch length = 40.33 is shown. This analysis involves 84 amino acid sequences, and there are a total of 1374 positions in the final dataset. b The optimal tree with the sum of branch length = 91.14 is shown. This analysis involves 129 amino acid sequences, and there are a total of 1010 positions in the final dataset. c Total QS&TCS entries with four protein annotations, i.e., “quorum sensing”, “LuxR”, “two-component”, and “tryptophanase”. d QS&TCS entries distribution of the seven-strain simplified human gut microbes used by Colosimo et al.⁴². e The overlap of the four types of QS&TCS entries in Escherichia coli O157:H7 strain. f QS&TCS entries count distribution of 818 human gut microbes from the VMH database²⁸. Note that the subgraph indicates the cumulative distribution curve for the statistics of the collected QS&TCS entries. The upper and lower insets show the probabilities and histogram, respectively. “Ranges” in the subgraph shows the range of the number of QS&TCS entries contained in each strain. The “Counts” and “Cumulative counts” in the subgraph represents the specific number of strains and proportion, respectively. Source data are provided as a Source Data file.