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. 2021 Nov 24;20(1):65–77. doi: 10.1007/s40201-021-00756-0

Table 2.

The toxicity responses (dose responses) to heavy metals as the oral reference doses (RfD) and oral slope factors (SF)

Heavy metal Oral reference dose (mg/kg/day) Dermal reference dose (mg/kg/day) Inhalation reference dose (mg/kg/day) Slope factor (mg/kg-day)−1
Ni 2 × 10−2 5.4 × 10−3 2.06 × 10−2 0.84
Pb 3.5 × 10−3 5.25 × 10−4 3.52 × 10−3 0.00085
Zn 0.3 6 × 10−2 0.3 n.d
Cu 4 × 10−2 1.2 × 10−2 4.02 × 10−2 n.d
Fe 1.6 n.d n.d n.d

n.d: not determined