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. 2022 May 20;13:896198. doi: 10.3389/fphar.2022.896198

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Copyright © 2022 He, Zhou, Cheng, Li, Gao, Ma, Song, Bai, Zou, Xiao, Wang and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Serum metabolite profile related to fibrosis in patients with chronic DILI. (A,B) Principal components analysis (PCA) of all variables among the NF, SF, and AF groups under the positive and negative models of mass spectrometry. (C,D) Orthogonal projections to latent structures discriminant analysis (OPLS-DA) of all variables among NF, SF, and AF groups under the positive and negative models of mass spectrometry. (E) PCA plot of (SF + AF) vs. NF with 273 annotated metabolites related to fibrosis. (F) PCA plot of SF vs. AF with 96 annotated metabolites related to advanced fibrosis. NF, nonsignificant fibrosis; SF, significant fibrosis; AF, advanced fibrosis.