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. 2022 May 20;13:879317. doi: 10.3389/fphar.2022.879317

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Copyright © 2022 Nie, Chen, Gao, Huang, Cao, Peng, Guo, Wang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The mechanism of ferroptosis. The core mechanisms affecting ferroptosis are mainly iron metabolism, lipid peroxidation and amino acid metabolism. ACAC, acetyl CoA carboxylase; ACSL4, acyl-CoA synthetase long-chain member 4; Cys, cysteine; Cys2, cystine; Fe2+, ferrous ion; Fe3+, ferric ion; Fpn, ferroportin; Glu, glutamate; Gly, glycine; GPX4, glutathione peroxidase 4; GSH, glutathione; H2O2, hydrogen peroxide; LPCAT3, lysophosphatidylcholine acyl-transferase 3; LOXs, lipoxygenases; NCOA4, nuclear receptor coactivator 4; Nrf2, nuclear factor erythroid 2-related factor 2; O2, oxygen; O2, Oxygen free radicals, PUFA, polyunsaturated fatty acids; PUFA-CoA, polyunsaturated fatty acids-CoA; PUFA-PL, polyunsaturated fatty acids-phospholipids; PL-PUFA-OOH, phospholipids-polyunsaturated fatty acids-peroxide; SLC3A2, solute carrier family 3 member 2; SLC7A11, solute carrier family 7 member 11; TCA, tricarboxylic acid cycle.