TABLE 4.
Chronological trend of recommendations on drug therapy for prevention of VAP.
| Guidelines | Enteral Nutrition (SOR/LOE) | SOD (SOR/LOE) | SDD (SOR/LOR) | Chlorhexidine (SOR/LOE) | Probiotics (SOR/LOE) | Ulcer Prophylaxis (SOR/LOE) | Aerosol Inhalation (SOR/LOE) |
|---|---|---|---|---|---|---|---|
| Collins, T. 2020 (Collins et al., 2020) | —— | —— | —— | Moderate/High | —— | —— | —— |
| Qu, JM 2018 (Infectious disease group RmboCMA 2018) | Moderate/Moderate | Moderate/Moderate | Moderate/Moderate | Strong/Moderate | Moderate/Moderate | Moderate/Moderate | —— |
| Torres, A. 2017 (Torres et al., 2017) | —— | Weak/Low | —— | No formal recommendation | —— | —— | —— |
| Mehta, Y. 2014 (Mehta et al., 2014) | —— | —— | —— | Strong/High | —— | —— | —— |
| Klompas, M. 2014 (Klompas et al., 2014) | —/Moderate | —/High | —— | —/Moderate | —/Moderate | —/Moderate | —— |
| Alvarez-Lerma, F. 2014 (Álvarez Lerma et al., 2014) | —— | Strong/High | Strong/High | Strong/Moderate | —— | —— | —— |
| Li, YM 2013 (Association CcmboCM 2013) | Weak/Moderate | Weak/Moderate | Weak/Moderate | Strong/Low | Weak/Moderate | —— | Weak/Low |
Strongly recommended Moderate recommended Weakly recommended; Recommended (not have the SOR) Strongly not recommended Moderate not recommended Weakly not recommended; Not recommended (not have the SOR, or no formal recommendation).SDD: selective digestive decontamination; SOD: selective oral decontamination; SOR: Strength of recommendation; LOE: Level of evidence.