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. 2022 Apr 29;298(6):101994. doi: 10.1016/j.jbc.2022.101994

Figure 1.

Figure 1

Binding of TβRI and TβRII by TGM-D1, TGM-D2, TGM-D3, TGM-D12, and TGM-FL as assessed by SPR.A–J, SPR sensorgrams obtained upon injection of TGM-D1 (A, F), TGM-D2 (B, G), TGM-D3 (C and H), TGM-FL (D and I), or TGM-D12 (E and J) over immobilized TβRI (A–E) or TβRII (F–J). Sensorgrams, obtained upon injections of a 2-fold dilution series of each TGM construct, are shown in black, with the fitted curves in orange (data for TGM-D1:TβRI, TGM-D3:TβRI, TGM-D1:TβRII, TGM-D2:TβRII, and TGM-D12:TβRII were not fit due to weak signal). Black bars shown above the sensorgrams specify the injection period. Injected concentrations are shown in the lower right. SPR, surface plasmon resonance.