Table 1.
Demographic and disease characteristics in patients with ulcerative colitis (UC) with fatigue and none fatigue
| Variables | Total (n = 220) | Fatigue (n = 136) | None fatigue(n = 84) | P value |
|---|---|---|---|---|
| Gender, n (%) | ||||
| Male | 131 (59.5) | 80 (58.8) | 51 (60.7) | 0.781 |
| Female | 89 (40.5) | 56 (41.2) | 33 (39.3) | |
| Age, year, median (IQR) | 45 (33–56) | 44 (32–56) | 48 (35–57) | 0.177 |
| Education, n (%) | ||||
| Master degree or above | 9 (4.1) | 5(3.7) | 4(4.8) | 0.861 |
| Undergraduate | 62 (28.2) | 37 (27.2) | 25 (29.8) | |
| Junior college | 39 (17.7) | 23 (16.9) | 16 (19.0) | |
| Senior high school or below | 110 (50.0) | 71 (52.2) | 39 (46.4) | |
| Employment status, n (%) | ||||
| Full time or part time | 151 (68.6) | 91 (66.9) | 60 (71.4) | 0.134 |
| No work | 15 (6.8) | 13 (9.6) | 2 (2.4) | |
| Retired | 37 (16.8) | 20 (14.7) | 17 (20.2) | |
| Other | 17 (7.7) | 12 (8.8) | 5 (6.0) | |
| Only child, n (%) | ||||
| Yes | 70 (31.8) | 47(34.6) | 23(27.4) | 0.267 |
| No | 150 (68.2) | 89(65.4) | 61 (72.6) | |
| Disease duration, year, median (IQR) | 3.9 (1.3–7.9) | 4.0 (1.4–8.0) | 3.8 (1.1–6.7) | 0.649 |
| Montreal classification, n (%) | ||||
| E1 | 39 (17.7) | 16 (11.8) | 23 (27.4) | < 0.001 |
| E2 | 66 (30.0) | 33 (24.3) | 33 (39.3) | |
| E3 | 115 (52.3) | 87 (64.0) | 28 (33.3) | |
| Disease activity, n (%) | ||||
| Remission | 50 (22.7) | 20 (14.7) | 30 (35.7) | < 0.001 |
| Mild | 88 (40.0) | 47 (34.6) | 41 (48.8) | |
| Moderate | 59 (26.8) | 47 (34.6) | 12 (14.3) | |
| Severe | 23 (10.5) | 22 (16.2) | 1 (1.19) | |
| EIM, n (%) | ||||
| Yes | 65 (29.5) | 38 (27.9) | 27 (32.1) | 0.507 |
| No | 155 (70.5) | 98 (72.1) | 57 (67.9) | |
| Complications, n (%) | ||||
| Yes | 12 (5.5) | 5 (3.68) | 7 (8.3) | 0.241 |
| No | 208 (94.5) | 131 (96.3) | 77 (91.7) | |
| Medication have been used, n (%) | ||||
| 5-ASA | 216 (98.2) | 133 (97.8) | 83 (98.8) | 0.686 |
| Immunosuppressants | 10 (4.5) | 6 (4.4) | 4 (4.8) | |
| Corticosteroids | 57 (25.9) | 40 (29.4) | 17 (20.2) | |
| Biologic treatment | 8 (3.6) | 5 (3.7) | 3 (3.6) | |
| IBD related surgery, n (%) | ||||
| Yes | 10 (4.5) | 8 (5.9) | 2 (2.4) | 0.226 |
| No | 210 (95.5) | 128 (94.1) | 82 (97.6) | |
| Anemia | ||||
| Yes | 49 (22.3) | 38 (77.6) | 11 (22.5) | 0.01 |
| No | 171(77.7) | 98 (57.3) | 73 (42.7) | |
| Smoking status, n (%) | ||||
| Yes | 42(19.1) | 26 (19.1) | 16 (19.0) | 0.99 |
| No | 178(80.9) | 110 (80.9) | 68 (81.0) | |
| Drinking status, n (%) | ||||
| Yes | 185 (80.1) | 21 (15.4) | 14 (16.7) | 0.809 |
| No | 35 (15.9) | 115 (84.6) | 70 (83.3) | |
| BMI, n (%) | ||||
| Thinnish | 34 (15.5) | 24 (17.6) | 10 (11.9) | 0.32 |
| Normal | 136 (61.8) | 79 (58.1) | 57 (67.9) | |
| Overweight or Obesity | 50 (22.7) | 33 (24.3) | 17 (20.2) | |
| FSS, median (IQR) | 4.4 (3.3–5.9) | 5.4 (4.6–6.3) | 2.7 (2.0–3.3) | < 0.001 |
| MFI, median (IQR) | 61 (48–73) | 68.5 (60–78) | 48 (37.3–58) | < 0.001 |
| HAS, median (IQR) | 5 (3–8) | 7 (4–10) | 4 (2–6) | < 0.001 |
| HDS, median (IQR) | 6 (3–9) | 7 (4–10) | 5 (2.25–7) | < 0.001 |
| PSQI, median (IQR) | 6 (4–9) | 7 (5–10) | 5 (3–8) | 0.001 |
| MUST, median (IQR) | 1 (0–2) | 1 (0–2) | 0 (0–1) | 0.001 |
IQR indicates interquartile range, E1, Proctitis; E2, Left side colitis; E3, Extensive colitis; EIM extra-intestinal manifestations; 5-ASA 5-aminosalisylic acid, IBD inflammatory bowel disease, BMI body mass index, HAS hospital anxiety scale, HDS hospital depression scale, PSQI pittsburgh sleep quality index, MUST malnutrition universal screening tool